Its hemodynamic effects occur by directly stimulating afferent arteriolar constriction as well as mesangial cell activity influencing Kf, and perhaps additional activity related to vascular obstruction inflammation, vide infra and cell toxicity.
For example, Endonuclease G Endo G is a small 27 kDa protein residing in the inner membrane space of mitochondria and can traverse to the nucleus under apoptotic conditions.
The resultant decrease in capillary structures has a number of potential consquences on renal function including the exacerbation of hypoxia and the impairment of Na handling hemodynamic responses.
Please if you notice any errors which make this publication unusable.